V.K. Golay

It is well known among researchers that the SIR genes are activated by the sensing of low NADH relative to NAD a measure of cellular redox state in animals from yeast to mammals. I have found that a mono-food high cyanogenic cassava root diet will produce low NADH levels as soon as all other nutrition clears the large intestine in 5-7 days. Other survival genes may also be activated when the large intestine becomes clear of bacteria, fat, iron and high protein as the large intestine is central to other longevity gene signaling involving nutrient sensing. The root can be characterized as high carbohydrate, high cyanogenic glucoside, no fat and low protein food. It is low in Methionine, Histidine, Tyrosine, and Tryptophan. While not adaquate for growth, or sustainable nutrition one can achieve low NADH (as measured by blood pyruvate being at or below the low reference range of 0.3 mg./dl. Normal reference range is 0.3-0.7 . Doing the diet in 2 week intervals with one replenishing meal between intervals one can sustain a low NADH condition for 50-60% of ones time. The author will produce test records, and in a poster demonstration discuss the possible molecular factors involved with this high cyanide carbohydrate. While not perfect I find it a doable regime that could be used in desperate situations.

Keywords (Optional): 
cyanogenic glucosides
NADH reduction
SIRT1-7 activation
iron chelation