Abstract Archive

This searchable list includes the abstracts of all presentations given at a conference organised as part of the SENS series. We regret that the videos recorded at SENS3 and SENS4 are currently unavailable.

Have we reached the point for in vivo rejuvenation?

Authors: A. Abramovich, V. Fraifeld

To date, the efficacy of replacement therapy by means of autologous stem cells is hindered by at least 3 factors: (i) the lack of sufficient number of autologous stem cells; (ii) the existence of stem cells with aged-phenotype of reduced repair capacity; (iii) the reduced potential of replacement therapy to repair non- or slow-turnover tissues. Lately, groundbreaking research has shown that somatic cells may be reprogrammed to a pluripotent state by the induction of a specific set of genes in vitro – creating induced pluripotent stem cells (iPS).

Keywords: aging, cell reprogramming, induced pluripotent stem cells, rejuvenation in vivo

Common gene signature of longevity and age-related diseases

Authors: A. Budovsky, A. Abramovich, H. Yanai, V. Fraifeld

We constructed the Human Longevity Network (HLN) and the networks for the major age-related degenerative diseases (ARDs) including atherosclerosis, cancer, Altzheimer's disease, and diabetes type II, based on protein-protein interactions. There is a remarkable overlap between the HLN and the ARD networks, suggesting that common pathways stand behind both aging and age-related pathology. The common genes are highly evolutionary conserved and fall into three main categories: signal transduction, DNA maintenance and repair, and protein and energy metabolism.

Keywords: aging, age-related diseases, common gene signature, longevity, protein-protein interaction networks