MECHANISM(s) RESPONSIBLE FOR EXERCISE-INDUCED CARDIOPROTECTION
Scott K. Powers
Department of Exercise and Sport Sciences and Physiology, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
Myocardial ischemia-reperfusion (I-R) injury is the major event
contributing to the morbidity and mortality associated with coronary
artery disease. Although several factors contribute to I-R-mediated
myocardial injury, compelling evidence indicates that generation of
radicals and other reactive oxygen species are important mediators of
this type of cardiac damage. Importantly, endurance exercise has been
shown to provide significant cardioprotection against an I-R insult.
This tutorial lecture will discuss the mechanism(s) responsible for
exercise-mediated cardioprotection. In particular, recent experiments
investigating the role of heat shock proteins in exercise-induced
cardioprotection will be highlighted. Further, the role that endogenous
antioxidants play in exercise-induced cardioprotection will also be
discussed. Finally, future directions for cardioprotection research
will be explored.
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