Senescence Marker Protein-30 (SMP30) as a novel anti-ageing molecule
D. Feng, Y. Kondo, A. Ishigami, M. Kuramoto, T. Machida, N. Maruyama
Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan
The expression of SMP30 having multifunctions is decreased with ageing
in almost all organs. The amino acid sequence of SMP30 is highly
conserved among various species. Intracellular localization of SMP30 is
both in cytoplasm and nucleus. Since a part of SMP30 is phosphorylated
, we determined phosphorylation sites by proteomic analysis. In
addition SMP30 catabolizes organophosphates in the presence of cationic
ions except calcium ion. Although SMP30 has been thought to be a
calcium-binding protein, our study showed no eveidence on its binding
to calcium ion. Another critical function of SMP30 on oxidative stress
will be discussed. Our study confirmed the critical role of SMP30 as an
anti-ageing.
Key words:
SMP30, phosphorylation, organophosphatase
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