Effects of oxidation, s-nitrosylation and glutathionylation on cathepsin D enzymatic activity

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Effects of oxidation, s-nitrosylation and glutathionylation on cathepsin D enzymatic activity

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This project is part of the following research theme(s):

LysoSENS

Project Description

Cathepsin D is a protease thought to be involved in the breakdown of hyperphosphorylated tau protein aggregates, a hallmark of Alzheimer's Disease. In this project, we investigate the effects of various chemical modifications (including oxidation, s-nitrosylation and glutathionylation) on the enzymatic activity of Cathepsin D.